Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

@article{Butt2005DownstreamTO,
  title={Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.},
  author={Alison Joy Butt and Catriona Mcneil and Elizabeth A. Musgrove and Robert Lyndsay Sutherland},
  journal={Endocrine-related cancer},
  year={2005},
  volume={12 Suppl 1},
  pages={S47-59}
}
Antioestrogen therapy is a highly effective treatment for patients with oestrogen-receptor (ER)-positive breast cancer, emphasising the central role of oestrogen action in the development and progression of this disease. However, effective antioestrogen treatment is often compromised by acquired endocrine resistance, prompting the need for a greater understanding of the down-stream mediators of oestrogen action that may contribute to this effect. Recent studies have demonstrated a critical link… CONTINUE READING

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