Downstream regulator TANK binds to the CD40 recognition site on TRAF3.

@article{Li2002DownstreamRT,
  title={Downstream regulator TANK binds to the CD40 recognition site on TRAF3.},
  author={C. Li and C. Ni and Marnie L. Havert and E. Cabezas and Jeannie Q. He and D. Kaiser and John Calvin Reed and A. Satterthwait and G. Cheng and K. R. Ely},
  journal={Structure},
  year={2002},
  volume={10 3},
  pages={
          403-11
        }
}
TRAFs (tumor necrosis factor receptor [TNFR]-associated factors) bind to the cytoplasmic portion of liganded TNFRs and stimulate activation of NF-kappaB or JNK pathways. A modulator of TRAF signaling, TANK, serves as either an enhancer or an inhibitor of TRAF-mediated signaling pathways. The crystal structure of a region of TANK bound to TRAF3 has been determined and compared to a similar CD40/TRAF3 complex. TANK and CD40 bind to the same crevice on TRAF3. The recognition motif PxQxT is… Expand
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