Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.

@article{Mihrshahi2010DownstreamOT,
  title={Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.},
  author={Robin Mihrshahi and Marion H Brown},
  journal={Journal of immunology},
  year={2010},
  volume={185 12},
  pages={7216-22}
}
The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein downstream of tyrosine kinase 2 (Dok2) and the subsequent recruitment and activation of Ras GTPase-activating protein (RasGAP). Ligand engagement of CD200R also results in tyrosine phosphorylation of Dok1, but this protein is not essential for inhibitory CD200R signaling in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…