Downstream of Otx2, or how to get a head.

  title={Downstream of Otx2, or how to get a head.},
  author={E. Boncinelli and Richard K. Morgan},
  journal={Trends in genetics : TIG},
  volume={17 11},
Otx2 is a member of a highly conserved family of homeodomain-containing transcription factors that function in early brain development. Recent studies have identified a significant number of target genes downstream of Otx2, allowing us to address the question of how it fulfils its diverse developmental roles. Interestingly, many of these target genes are not transcription factors or signaling molecules, and they probably have no direct affect on gene expression. Furthermore, there is evidence… CONTINUE READING

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