Downstream drug product processing of itraconazole nanosuspension: Factors influencing tablet material properties and dissolution of compacted nanosuspension-layered sugar beads.

@article{Tan2017DownstreamDP,
  title={Downstream drug product processing of itraconazole nanosuspension: Factors influencing tablet material properties and dissolution of compacted nanosuspension-layered sugar beads.},
  author={En Hui Tan and Johannes Parmentier and Ariana Qiao Jun Low and Jan Peter M{\"o}schwitzer},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={532 1},
  pages={
          131-138
        }
}
There has been limited research done on the downstream processing of nanosuspensions into solid oral dosage forms. This paper demonstrates the bead layering process with a layering level at 150% and 240%, as well as the selection and justification of the outer phase excipients for tabletability and disintegrating properties. In a previous study, an itraconazole nanosuspension stabilised by SDS and HPMC E5 was layered onto sugar beads with coating polymer HPMC VLV. In the current study… CONTINUE READING