Downregulation of vaccinia virus intermediate and late promoters by host transcription factor YY1.

@article{Knutson2009DownregulationOV,
  title={Downregulation of vaccinia virus intermediate and late promoters by host transcription factor YY1.},
  author={Bruce A Knutson and Jaewook Oh and Steven S. Broyles},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 7},
  pages={1592-9}
}
Approximately half of the intermediate and late gene transcriptional promoters of vaccinia virus have a binding site for the cellular transcription factor YY1 that overlaps the initiator elements. Depletion of YY1 using RNA interference enhanced the activity of these promoters, while overexpression of YY1 repressed their activity. Viral promoter nucleotide replacements that specifically impair the binding of YY1 mostly alleviated the transcriptional repression and correlated with the ability of… CONTINUE READING
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