Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer

@inproceedings{Xiang2011DownregulationOT,
  title={Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer},
  author={Rong Xiang and Daiqing Liao and T Cheng and Hong-fei Zhou and Qian Shi and T H Chuang and Dorothy Markowitz and Ralph A. Reisfeld and Yanxin Luo},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:The cancer stem cell hypothesis suggests that neoplastic clones are maintained exclusively by a small subpopulation of cells, which have indefinite proliferation and differentiation potentials and give rise to phenotypically diverse cancer cells. Cancer stem cells have been isolated by their ability to efflux Hoechst 33342 dye and are referred to as the ‘side population’ (SP).Methods and results:The Hoechst efflux assay was used to isolate and characterize the SP from murine D121… CONTINUE READING