Downregulation of the sodium channel Nav1.6 by potential transcriptomic deregulation may explain sensory deficits in critical illness neuropathy.

@article{Li2015DownregulationOT,
  title={Downregulation of the sodium channel Nav1.6 by potential transcriptomic deregulation may explain sensory deficits in critical illness neuropathy.},
  author={Nan Li and Zhongmin Liu and Guang Wang and Shiji Wang},
  journal={Life sciences},
  year={2015},
  volume={143},
  pages={
          231-6
        }
}
AIMS Sepsis patients and other patients in the critical care settings are at very high risk of mortality due to the primary illness. However, a fraction of patients, even after showing initial clinical improvement, deteriorates relentlessly at later stages. Increasingly, it is being identified that this is mostly due to dysfunction of the neurological system. MAIN METHODS We obtained peripheral nerve biopsies from the sural nerve from ICU patients. Nav1.6 expression was significantly… CONTINUE READING
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