Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes

@inproceedings{Petrosyan2015DownregulationOT,
  title={Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes},
  author={Armen Vasil Petrosyan and P. Daniel Cheng and Dahn L. Clemens and Carol A. Casey},
  booktitle={Scientific reports},
  year={2015}
}
The hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationally modified in the Golgi en route to the plasma membrane, where it mediates clearance of desialylated serum glycoproteins. It is known that content of plasma membrane-associated ASGP-R is decreased after ethanol exposure, although the mechanisms remain elusive. Previously, we found that… CONTINUE READING