Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.

@article{Fuchs2010DownregulationOT,
  title={Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.},
  author={Andrea Fuchs and Cornelia Ringer and Andras Bilkei-Gorzo and Eberhard Weihe and Jochen Roeper and Birgit Sch{\"u}tz},
  journal={Journal of neuropathology and experimental neurology},
  year={2010},
  volume={69 10},
  pages={
          1057-70
        }
}
The balance between excitatory and inhibitory synaptic inputs is critical for the physiological control of motoneurons. The maintenance of a low-intracellular chloride concentration by the potassium chloride cotransporter 2 (KCC2) is essential for the efficacy of fast synaptic inhibition of mature motoneurons in response to the activation of ionotropic γ-aminobutyric acid A and glycine receptors. Altered synaptic balance and excitotoxicity have been proposed as candidate pathophysiological… CONTINUE READING

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