Downregulation of the nuclear-encoded subunits of the complexes III and IV disrupts their respective complexes but not complex I in procyclic Trypanosoma brucei.

@article{Horvth2005DownregulationOT,
  title={Downregulation of the nuclear-encoded subunits of the complexes III and IV disrupts their respective complexes but not complex I in procyclic Trypanosoma brucei.},
  author={Anton Horv{\'a}th and Eva Hor{\'a}kov{\'a} and Petra Dunajc{\'i}kov{\'a} and Zdeněk Verner and Eliska Pravdov{\'a} and Iveta Slapetov{\'a} and L'udmila Cuninkov{\'a} and Julius Luke{\vs}},
  journal={Molecular microbiology},
  year={2005},
  volume={58 1},
  pages={116-30}
}
The function, stability and mutual interactions of selected nuclear-encoded subunits of respiratory complexes III and IV were studied in the Trypanosoma brucei procyclics using RNA interference (RNAi). The growth rates and oxygen consumption of clonal cell lines of knock-downs for apocytochrome c1 (apoc1) and the Rieske Fe-S protein (Rieske) of complex III, and cytochrome c oxidase subunit 6 (cox6) of complex IV were markedly decreased after RNAi induction. Western analysis of mitochondrial… CONTINUE READING

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