Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma.

@article{Zhu2013DownregulationOT,
  title={Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma.},
  author={Ying-hui Zhu and Li Fu and Leilei Chen and Yan-ru Qin and Haibo Liu and Fajun Xie and Tingting Zeng and Sui-sui Dong and Jiangchao Li and Yan Li and Yongdong Dai and Dan Xie and Xin-yuan Guan},
  journal={Cancer research},
  year={2013},
  volume={73 7},
  pages={
          2298-309
        }
}
Loss of chromosome 19p is one of the most frequent allelic imbalances in esophageal squamous cell carcinoma (ESCC), suggesting the existence of one or more tumor suppressor genes within this region. In this study, we investigated a role in ESCCs for a candidate tumor suppressor gene located at 19p13.3, the Ras-like small GTPase DIRAS1. Downregulation of DIRAS1 occurred in approximately 50% of primary ESCCs where it was associated significantly with advanced clinical stage, lymph node metastasis… CONTINUE READING

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References

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SHOWING 1-10 OF 48 REFERENCES

Overexpression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.

  • Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • 2009

DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2008

Cancer statistics, 2007.

  • CA: a cancer journal for clinicians
  • 2007