Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes.

@article{Seiberlich2015DownregulationOT,
  title={Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes.},
  author={Veronika Seiberlich and Nina G. Bauer and Lisa Schwarz and Charles ffrench-Constant and Olaf Goldbaum and Christiane Richter-Landsberg},
  journal={Glia},
  year={2015},
  volume={63 9},
  pages={1621-35}
}
Oligodendrocytes, the myelin forming cells of the CNS, are characterized by their numerous membranous extensions, which enwrap neuronal axons and form myelin sheaths. During differentiation oligodendrocytes pass different morphological stages, downregulate the expression of the proteoglycan NG2, and acquire major myelin specific proteins, such as myelin basic proteins (MBP) and proteolipid protein. MBP mRNA is transported in RNA granules along the microtubules (MTs) to the periphery and… CONTINUE READING
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