Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

@article{Marwitz2016DownregulationOT,
  title={Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.},
  author={Sebastian Marwitz and Sofia Depner and Dmytro Dvornikov and Ruth Merkle and Magdalena Szczygieł and Karin Mueller-Decker and Philippe Lucarelli and Marvin W{\"a}sch and Heimo Mairb{\"a}url and Klaus Friedrich Rabe and Christian Kugler and Ekkehard Vollmer and Martin Reck and Swetlana Scheufele and Maren Kr{\"o}ger and Ole Ammerpohl and Reiner Siebert and Torsten Goldmann and Ursula Klingm{\"u}ller},
  journal={Cancer research},
  year={2016},
  volume={76 13},
  pages={3785-801}
}
Non-small cell lung cancer (NSCLC) is characterized by early metastasis and has the highest mortality rate among all solid tumors, with the majority of patients diagnosed at an advanced stage where curative therapeutic options are lacking. In this study, we identify a targetable mechanism involving TGFβ elevation that orchestrates tumor progression in this disease. Substantial activation of this pathway was detected in human lung cancer tissues with concomitant downregulation of BAMBI, a… CONTINUE READING
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