Downregulation of the GnT-V gene inhibits metastasis and invasion of BGC823 gastric cancer cells.

  title={Downregulation of the GnT-V gene inhibits metastasis and invasion of BGC823 gastric cancer cells.},
  author={Binbin Huang and Longe Sun and Jianchun Cao and Yunyun Zhang and Qiong Wu and Junjie Zhang and Yanli Ge and Liu He Bochen Fu and Zhirong Wang},
  journal={Oncology reports},
  volume={29 6},
Metastatic and invasive potential is a barrier to the successful treatment of gastric cancer. N-acetylgluco-saminyltransferase V (GnT-V), a key enzyme catalyzing the formation of 1,6 N-acetylglucosamine (GlcNAc), has been demonstrated to display a distinct function in different types of tumors. The aim of this study was to investigate the role of GnT-V in the invasive potential of BGC823 human gastric cancer cells in vitro and the possible underlying mechanism. GnT-V was downregulated in BGC823… CONTINUE READING


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