Downregulation of protein kinase C-α enhances intracellular survival of Mycobacteria: role of PknG

@inproceedings{Chaurasiya2009DownregulationOP,
  title={Downregulation of protein kinase C-α enhances intracellular survival of Mycobacteria: role of PknG},
  author={Shivendra Kumar Chaurasiya and Kishore K. Srivastava},
  booktitle={BMC Microbiology},
  year={2009}
}
Intracellular trafficking of mycobacteria is comprehensively dependent on the unusual regulation of host proteins. Recently, we have reported that infection of macrophages by Mycobacterium tuberculosis H37Rv (Rv) selectively downregulates the expression of PKCα while infection by Mycobacterium smegmatis (MS) does not. Based on our earlier study, we have extrapolated for the first time that knockdown of PKCα, impairs phagocytosis of mycobacteria by macrophages while their intracellular survival… CONTINUE READING

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