Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia.

@article{Lee2001DownregulationOP,
  title={Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia.},
  author={Xinhua Lee and J. S. Keith and N Stumm and Ioannis K Moutsatsos and John M. McCoy and Christopher P Crum and David Genest and David C. W. Chin and Christian von Ehrenfels and Robert Pijnenborg and Frans Andr{\'e} Van Assche and Sha Mi},
  journal={Placenta},
  year={2001},
  volume={22 10},
  pages={808-12}
}
Development of placentation and successful pregnancy depend on co-ordinated interactions between the maternal decidua and myometrium, and the invasive properties of the fetal trophoblast. Syncytin, a protein encoded by the envelope gene of a recently identified human endogenous defective retrovirus, HERV-W, is highly expressed in placental tissue. Previously, we have shown that the major site of syncytin expression is the placental syncytiotrophoblast, a fused multinuclear syncytium originating… CONTINUE READING