Downregulation of parathyroid hormone receptor gene expression and osteoblastic dysfunction associated with skeletal resistance to parathyroid hormone in a rat model of renal failure with low turnover bone.

@article{IwasakiIshizuka2005DownregulationOP,
  title={Downregulation of parathyroid hormone receptor gene expression and osteoblastic dysfunction associated with skeletal resistance to parathyroid hormone in a rat model of renal failure with low turnover bone.},
  author={Yoshiko Iwasaki-Ishizuka and Hideyuki Yamato and Tomoko Nii-Kono and Kiyoshi Kurokawa and Masafumi Fukagawa},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2005},
  volume={20 9},
  pages={1904-11}
}
BACKGROUND Adynamic bone disease (ABD), which is characterized by reduced bone formation and resorption, has become an increasingly common manifestation of bone abnormalities in patients with end-stage renal failure. It has been recognized that skeletal resistance to parathyroid hormone (PTH) underlies the pathogenesis of ABD; however, the mechanisms of such resistance remain unclear. METHODS We established a rat model simulating ABD under chronic renal failure conditions by… CONTINUE READING