Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.

@article{Chipoy2004DownregulationOO,
  title={Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.},
  author={C{\'e}line Chipoy and Martine Berreur and S{\'e}verine Couillaud and Gilbert Pradal and François Marie Vallette and Caroline Colombeix and Françoise R{\'e}din{\'i} and Dominique Heymann and Fr{\'e}d{\'e}ric Blanchard},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2004},
  volume={19 11},
  pages={1850-61}
}
UNLABELLED The effects of OSM on proliferation and differentiation of osteosarcoma and nontransformed osteoblasts were analyzed. OSM downregulates osteoblast markers but induces the glial fibrillary acidic protein by the combined activation of PKCdelta and STAT3, offering new lines of therapeutic investigations. INTRODUCTION Oncostatin M (OSM) is a multifunctional cytokine of the interleukin-6 family implicated in embryonic development, differentiation, inflammation, and regeneration of… CONTINUE READING

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