Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to delay the onset of Alzheimer's disease (AD). NSAIDs inhibit cyclooxygenase (COX), of which two isoforms exist. We report decreased neuronal COX-2 expression in AD subjects relative to nondemented controls using qualitative analysis of COX-2 immunoreactivity and quantification of COX-2 positive neurons… (More)

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Cite this paper

@article{Yermakova2001DownregulationON, title={Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease.}, author={Anna Yermakova and M Kerry O'Banion}, journal={Neurobiology of aging}, year={2001}, volume={22 6}, pages={823-36} }