Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

@article{Saretzki2008DownregulationOM,
  title={Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.},
  author={Gabriele Saretzki and Theresia Walter and Stuart P. Atkinson and Jo{\~a}o F. Passos and Bettina Bareth and W. Nicol Keith and Rebecca Marie Stewart and Stacey Hoare and Miodrag Stojkovi{\'c} and Lyle Armstrong and Thomas von Zglinicki and Majlinda Lako},
  journal={Stem cells},
  year={2008},
  volume={26 2},
  pages={455-64}
}
Evolutionary theory predicts that cellular maintenance, stress defense, and DNA repair mechanisms should be most active in germ line cells, including embryonic stem cells that can differentiate into germ line cells, whereas it would be energetically unfavorable to keep these up in mortal somatic cells. We tested this hypothesis by examining telomere maintenance, oxidative stress generation, and genes involved in antioxidant defense and DNA repair during spontaneous differentiation of two human… CONTINUE READING
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