Downregulation of multiple CDK inhibitor ICK/KRP genes upregulates the E2F pathway and increases cell proliferation, and organ and seed sizes in Arabidopsis.

@article{Cheng2013DownregulationOM,
  title={Downregulation of multiple CDK inhibitor ICK/KRP genes upregulates the E2F pathway and increases cell proliferation, and organ and seed sizes in Arabidopsis.},
  author={Yan Cheng and Ling Cao and Sheng Wang and Yongpeng Li and Xianzong Shi and Han Liu and Lixia Li and Zhengli Zhang and Larry C. Fowke and Hong Wang and Yongming Zhou},
  journal={The Plant journal : for cell and molecular biology},
  year={2013},
  volume={75 4},
  pages={642-55}
}
The ICK/KRP cyclin-dependent kinase (CDK) inhibitors are important plant cell cycle factors sharing only limited similarity with the metazoan CIP/KIP family of CDK inhibitors. Little is known about the specific functions of different ICK/KRP genes in planta. In this study, we created double and multiple mutants from five single Arabidopsis ICK/KRP T-DNA mutants, and used a set of 20 lines for the functional investigation of the important gene family. There were gradual increases in CDK activity… CONTINUE READING
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