Downregulation of mitochondrial lon protease impairs mitochondrial function and causes hepatic insulin resistance in human liver SK-HEP-1 cells

@article{Lee2011DownregulationOM,
  title={Downregulation of mitochondrial lon protease impairs mitochondrial function and causes hepatic insulin resistance in human liver SK-HEP-1 cells},
  author={Hye Ja Lee and K. Chung and K-U. Lee and Joo Hyun Lim and Jaewhan Song},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={1437-1446}
}
Lon protease degrades oxidatively damaged proteins in mitochondrial matrix. To examine the relationships between mitochondrial quality control, mitochondrial functions and diabetes, we investigated whether lon protease deficiency influences insulin resistance by affecting mitochondrial function. Lon protease-specific small interfering RNA (siRNA) was… CONTINUE READING