Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response.

  title={Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response.},
  author={Changzhi Xu and Xiang He and Zirui Zheng and Zhe Zhang and Congwen Wei and Kai Guan and Li-hua Hou and Buchang Zhang and Lin Zhu and Yuan Guang Cao and Yanhong Zhang and Ye Shi Cao and Shengli Ma and PengHao Wang and Pingping Zhang and Quanbin Xu and Youguo Ling and Xiao Ming Yang and Hui Zhong},
  journal={Journal of virology},
  volume={88 19},
UNLABELLED Retinoic acid-inducible gene I (RIG-I) is an intracellular RNA virus sensor that induces type I interferon-mediated host-protective innate immunity against viral infection. Although cylindromatosis (CYLD) has been shown to negatively regulate innate antiviral response by removing K-63-linked polyubiquitin from RIG-I, the regulation of its expression and the underlying regulatory mechanisms are still incompletely understood. Here we show that RIG-I activity is regulated by inhibition… CONTINUE READING
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