Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke.


Although microRNAs have been investigated extensively in cancer research, little is known regarding their response to noxious agents in apparently healthy tissues. We analyzed the expression of 484 miRNAs in the lungs of rats exposed to environmental cigarette smoke (ECS) for 28 days. ECS down-regulated 126 miRNAs (26.0%) at least 2-fold and 24 miRNAs more… (More)
DOI: 10.1096/fj.08-121384


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