Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14

@article{Ji2015DownregulationOM,
  title={Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14},
  author={Ming-liang Ji and Xuejun Zhang and Pei-liang Shi and Jun Lu and Shan-zheng Wang and Qing Chang and Hui Chen and Chen Wang},
  journal={Journal of Molecular Medicine},
  year={2015},
  volume={94},
  pages={457-468}
}
Accumulating evidence suggests that microRNAs (miRNAs) play an important role in intervertebral disc degeneration (IDD), but the precise role of specific miRNAs involved in this disease remains elusive. The purpose of this study was to identify IDD-specific miRNAs, followed by functional validation of results. MiRNA expression profile was determined in nucleus pulposus (NP) tissues from patients with IDD and controls, employing Solexa sequencing and quantitative real-time PCR (qRT-PCR… CONTINUE READING
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