Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells

@article{Wang2013DownregulationOM,
  title={Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells},
  author={Min Wang and Yuanyuan Wang and Wenqiao Zang and Huaqi Wang and Heying Chu and Ping Li and Min Li and Guojun Zhang and Guoqiang Zhao},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={39-46}
}
Lung cancer is a major cause of cancer death worldwide. Programmed cell death 4 (PDCD4), an important tumor suppressor, influences transcription and translation of multiple genes and modulates different signal transduction pathways. However, the upstream regulation of this gene is largely unknown. In our study, we found that microRNA-182 (miR-182) was upregulated, whereas PDCD4 was downregulated in lung cancer cell lines. We performed methyl thiazolyl tetrazolium and colony formation assays to… CONTINUE READING
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