Downregulation of microRNA‐135b promotes atherosclerotic plaque stabilization in atherosclerotic mice by upregulating erythropoietin receptor

@article{Wu2019DownregulationOM,
  title={Downregulation of microRNA‐135b promotes atherosclerotic plaque stabilization in atherosclerotic mice by upregulating erythropoietin receptor},
  author={Bowen Wu and Yu Liu and Mi-Shan Wu and Yun-Hui Meng and Meng Lu and Jin-Dong Guo and Yuhui Zhou},
  journal={IUBMB Life},
  year={2019},
  volume={72},
  pages={198 - 213}
}
Atherosclerotic plaque rupture is an important pathophysiologic mechanism of acute coronary syndrome. Emerging microRNAs (miRNAs) have been implicated in the atherosclerotic plaque formation and macrophage autophagy during the development of atherosclerosis (AS). Hence, this study was conducted to explore the role microRNA‐135b (miR‐135b) in macrophages and atherosclerotic plaque in mouse models of AS. The expression of miR‐135b and erythropoietin receptor (EPOR) was altered in atherosclerotic… 
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Apoptosis, autophagy and atherosclerosis: relationships and the role of Hsp27.
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MiR-29a elevation induces the increase of autophagy by down-regulating the PI3K/AKT/mTOR pathway in the progression of AS, indicating that miR- 29a is a novel therapeutic strategy for AS.
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