Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice.

@article{Mishra2011DownregulationOM,
  title={Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice.},
  author={Amartya Mishra and Sumit Paul and Snehasikta Swarnakar},
  journal={Biochimie},
  year={2011},
  volume={93 5},
  pages={854-66}
}
Matrix metalloproteinases (MMPs) have been implicated in inflammatory and degradative processes in several diseases. The study aims to explore the mechanism of MMP-9 regulation in alcohol-induced acute liver injury and its protection by melatonin in mice. Alcohol-induced acute liver injury was induced in female Balb/C mice by ethanol administration and protection studies were carried out with a well-known antioxidant molecule, melatonin. Degree of liver injury was monitored by histological and… CONTINUE READING

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