Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer

@article{Miyake2009DownregulationOM,
  title={Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer},
  author={Kotaro Miyake and M. Shimada and M. Nishioka and Koji Sugimoto and Erdenebulgan Batmunkh and Y. Uto and H. Nagasawa and H. Hori},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2009},
  volume={64},
  pages={885-892}
}
PurposeIt is well known that hypoxic milieu is the primary cancer environment. Therefore, tumor hypoxia is considered to be a potential therapeutic target. In the present study, we investigated the antitumor and antimetastatic effect of hypoxic cell radiosensitizer, TX-1877 on xenograft model of rectal cancer.MethodsNude mice bearing subcutaneously or orthotopically implanted human colon cancer cell lines HCT-116 and HT-29 were treated with TX-1877, irradiation or TX-1877 with irradiation… Expand
Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target
  • E. Fröhlich
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 2010
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