Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats.

@article{Tandon2002DownregulationOK,
  title={Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats.},
  author={Pushpa Tandon and Yili Yang and Carl E Stafstrom and Gregory L. Holmes},
  journal={Brain research. Developmental brain research},
  year={2002},
  volume={136 2},
  pages={
          145-50
        }
}
There are significant differences in seizure-induced sequelae between the immature and mature brain. We have previously demonstrated that repeated doses of the chemoconvulsant kainic acid is associated with a progressive increase in severity of seizures in adult animals while in immature rats the opposite occurs; seizure intensity decreases with subsequent doses of kainic acid. Likewise, repeated kainic acid seizures causes severe hippocampal damage in mature rats while in the immature brain… CONTINUE READING
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