Downregulation of integrin receptor-signaling genes by Epstein-Barr virus EBNA 3C via promoter-proximal and -distal binding elements.

@article{McClellan2012DownregulationOI,
  title={Downregulation of integrin receptor-signaling genes by Epstein-Barr virus EBNA 3C via promoter-proximal and -distal binding elements.},
  author={Michael J. McClellan and Sarika Khasnis and Christopher D. Wood and Richard D. Palermo and Sandra N. Schlick and Aditi Kanhere and Richard G Jenner and Michelle J West},
  journal={Journal of virology},
  year={2012},
  volume={86 9},
  pages={5165-78}
}
Epstein-Barr virus (EBV) establishes a persistent latent infection in B lymphocytes and is associated with the development of numerous human tumors. Epstein-Barr nuclear antigen 3C (EBNA 3C) is essential for B-cell immortalization, has potent cell cycle deregulation capabilities, and functions as a regulator of both viral- and cellular-gene expression. We performed transcription profiling on EBNA 3C-expressing B cells and identified several chemokines and members of integrin receptor-signaling… CONTINUE READING