Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats.

@article{Grillo2011DownregulationOH,
  title={Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats.},
  author={Claudia Alejandra Grillo and Gerardo G. Piroli and Kris F Kaigler and Steven P Wilson and Marlene A. Wilson and Lawrence P. Reagan},
  journal={Behavioural brain research},
  year={2011},
  volume={222 1},
  pages={230-5}
}
Ongoing epidemiological studies estimate that greater than 60% of the adult US population may be categorized as either overweight or obese. There is a growing appreciation that the complications of obesity extend to the central nervous system (CNS) and may result in increased risk for neurological co-morbidities like depressive illness. One potential mechanistic mediator linking obesity and depressive illness is the adipocyte derived hormone leptin. We previously demonstrated that lentivirus… CONTINUE READING
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