Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer.

@article{Zhang2014DownregulationOG,
  title={Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer.},
  author={Xianglan Zhang and Zhenlong Zheng and Shen Yingji and Hye Ok Kim and Ren-shun Jin and Li Renshu and Doo Young Lee and Mi Ryung Roh and Sang Hwa Yang},
  journal={Oncology reports},
  year={2014},
  volume={31 6},
  pages={
          2587-92
        }
}
Glutathione peroxidase 3 (GPX3) is a member of the glutathione peroxidase family of selenoproteins and is one of the key defensive enzymes against oxidative damages to host cells. Downregulation of GPX3 due to its promoter hypermethylation has been documented in several different types of cancer, indicating that GPX3 functions as a possible tumor suppressor. In the present study, we showed that GPX3 is also significantly downregulated in cervical cancer tissues compared to normal cervical… 
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Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma.
TLDR
Depletion of GPX3 was found to increase the proliferative ability, motility, and invasiveness of melanoma cells and negative expression of GPx3 was related to poor prognosis in melanoma patients.
Distinct prognostic values of mRNA expression of glutathione peroxidases in non-small cell lung cancer
TLDR
The current findings of prognostic values of individual mRNA expression of GPxs in NSCLC patients indicate some GPxs may have prognostic value in NSClC patients, and this needs further study.
Reduced Expression of GPX3 in Breast Cancer Patients in Correlation with Clinical Significance
TLDR
The results suggested that GPX3 plays a role in breast carcinogenesis, and might serve as a prognostic biomarker in breast cancer patients.
GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway
TLDR
GPX2 was highly expressed in cervical cancer tissues compared to normal individuals and promoted the proliferation and metastasis of cervical cancer by affecting oxidative stress, and this promotion correlated with the activation of EMT and WNT/β-catenin signaling in vitro.
GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
TLDR
It is found that the methylation rate in advanced cancers was significantly higher than that in early stage cancers by a methylation-specific polymerase chain reaction, and GPX3 has the potential as a novel biomarker in the diagnosis of ESCC.
Association between GPX3 promoter methylation and malignant tumors: A meta-analysis.
The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis.
5-Aza-2’-deoxycytidine inhibits proliferation and induces apoptosis in oral cancer cells by enhancing glutathione peroxidase-3 expression
TLDR
The results suggest that 5-Aza-Cd suppressed proliferation and accelerated apoptosis in oral cancer cells by inhibiting demethylation and thereby promoting GPX3 expression.
Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer
TLDR
Glutathione peroxidase 3 has a dichotomous role in different tumor types, acting as both a tumor suppressor and pro-survival protein, and how GPx3 might be targeted for therapeutic intervention is examined.
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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