Downregulation of fibulin-3 gene by promoter methylation in colorectal cancer predicts adverse prognosis.

@article{Tong2011DownregulationOF,
  title={Downregulation of fibulin-3 gene by promoter methylation in colorectal cancer predicts adverse prognosis.},
  author={Jianping Tong and Ning Jiao and Yu Xin Wang and Yun Wu Zhang and Fushi Han},
  journal={Neoplasma},
  year={2011},
  volume={58 5},
  pages={
          441-8
        }
}
Fibulin-3 gene has been identified as an antagonist of angiogenesis. We investigated the protein expression and promoter methylation status of fibulin-3 gene in colorectal cancer (CRC) and analyzed its correlation with clinicopathological factors. The study population enrolled 85 paired CRC specimens and adjacent normal tissues, as well as 32 cases of colorectal adenoma. Genomic DNA was extracted from paraffin-embedded samples using manual microdissection. Methylation-specific polymerase chain… CONTINUE READING

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