Downregulation of epithelial apoptosis and barrier repair in active Crohn ’ s disease by tumour necrosis factor a antibody treatment

@inproceedings{Zeissig2004DownregulationOE,
  title={Downregulation of epithelial apoptosis and barrier repair in active Crohn ’ s disease by tumour necrosis factor a antibody treatment},
  author={Sebastian Zeissig and Christina Bojarski and Nataly Buergel and Joachim Mankertz and Michael Zeitz and Michael Fromm},
  year={2004}
}
Background and aims: Barrier dysfunction is an important feature contributing to inflammation and diarrhoea in Crohn’s disease (CD). Recently, tumour necrosis factor a (TNF-a) antibodies were recognised as effective in steroid refractory CD. The aim of this study was to characterise the effects of this therapy on the epithelial barrier. Patients and methods: Forceps biopsies were obtained from the sigmoid colon before and 14 days after TNF-a antibody therapy in 11 patients treated for chronic… CONTINUE READING
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