Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke.

@article{Cai2002DownregulationOE,
  title={Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke.},
  author={Hua Cai and Zongming Li Li and Andreas Goette and Fernando V Mera and Clegg Honeycutt and Kristian Feterik and Josiah N. Wilcox and Samuel C Dudley and David G Harrison and J. J. Langberg},
  journal={Circulation},
  year={2002},
  volume={106 22},
  pages={2854-8}
}
BACKGROUND In the arterial endothelium, laminar flow and cyclical stretch induce expression of NO synthase (NOS). We hypothesized that atrial fibrillation (AF) causes a downregulation of atrial endocardial NOS expression and NO* production. Because NO* has antithrombotic properties, this may contribute to thromboembolism in AF. METHODS AND RESULTS In pigs, AF was produced with rapid atrial pacing at 600 bpm for 1 week, whereas controls had atrial pacing at 100 bpm. All animals production from… CONTINUE READING
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Molecular basis of electrical remodeling in atrial fibrillation

  • DR VanWagoner, JM Nerbonne
  • J Mol Cell Cardiol
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