Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.

@article{Volders1999DownregulationOD,
  title={Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.},
  author={P. G. A. Volders and Karin Sipido and Marc A. Vos and Roel L. H. M. G. Sp{\"a}tjens and Jet D. M. Leunissen and Edward E. Carmeliet and Hein J. J. Wellens},
  journal={Circulation},
  year={1999},
  volume={100 24},
  pages={2455-61}
}
BACKGROUND Acquired QT prolongation enhances the susceptibility to torsades de pointes (TdP). Clinical and experimental studies indicate ventricular action potential prolongation, increased regional dispersion of repolarization, and early afterdepolarizations as underlying factors. We examined whether K(+)-current alterations contribute to these proarrhythmic responses in an animal model of TdP: the dog with chronic complete atrioventricular block (AVB) and biventricular hypertrophy. METHODS… CONTINUE READING

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Enhanced cardiac contractile performance and sarcoplasmic reticulum Ca 21 release in dogs with chronic complete atrioventricular block

  • KR Sipido, Volders PGA, de Groot SHMA, MA Vos
  • 1998

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