Downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes.

@article{Shao2009DownregulationOC,
  title={Downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes.},
  author={Ruijin Shao and Magdalena Nutu and Linda Karlsson-Lindahl and Anna Benrick and Birgitta Weijdeg{\aa}rd and Susanne Lager and Emil Egecioglu and J. J. Fernandez-Rodriguez and Kristina Gemzell-Danielsson and C Ohlsson and J. -O. Jansson and H{\aa}kan Billig},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={297 1},
  pages={C140-51}
}
The action of interleukin-6 (IL-6) impacts female reproduction. Although IL-6 was recently shown to inhibit cilia activity in human fallopian tubes in vitro, the molecular mechanisms underlying IL-6 signaling to tubal function remain elusive. Here, we investigate the cellular localization, regulation, and possible function of two IL-6 receptors (IL-6R alpha and gp130) in mouse and human fallopian tubes in vivo. We show that IL-6R alpha is restricted to the cilia of epithelial cells in both… CONTINUE READING