Downregulation of cellular c-Jun N-terminal protein kinase and NF-κB activation by berberine may result in inhibition of herpes simplex virus replication.

@article{Song2014DownregulationOC,
  title={Downregulation of cellular c-Jun N-terminal protein kinase and NF-κB activation by berberine may result in inhibition of herpes simplex virus replication.},
  author={Siwei Song and Min Qiu and Ying Chu and Deyan Chen and Xiaohui Wang and Airong Su and Zhiwei Wu},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 9},
  pages={5068-78}
}
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. Some reports show that berberine exhibits anti-inflammatory, antitumor, and antiviral properties by modulating multiple cellular signaling pathways, including p53, nuclear factor κB (NF-κB), and mitogen-activated protein kinase. In the present study, we investigated the antiviral effect of berberine against herpes simplex virus (HSV) infection. Current antiherpes medicines such as acyclovir can… CONTINUE READING
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