Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells

@inproceedings{Comamala2011DownregulationOC,
  title={Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells},
  author={Marina Comamala and Maxime Pinard and Catherine Th{\'e}riault and Isabelle Matte and Adelin Albert and Marianne Boivin and Julie Beaudin and alain. piche and Claudine Rancourt},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinomas, suggesting a possible role in the… CONTINUE READING