Downregulation of caveolin-1 in chronic rhinosinusitis with and without nasal polyps

Abstract

The pathogenesis of human chronic rhinosinusitis (CRS) remains controversial. Recent evidence has suggested that caveolin-1 (Cav-1) is a 22 kDa scaffolding protein and plays a pivotal role in host defense against infections and tumour suppression by reducing production of cyclin D1 and endothelial nitric oxide-synthase (eNOS). However, little is known about… (More)
DOI: 10.1007/s00405-014-3146-8

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