Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells.

@article{Linge2007DownregulationOC,
  title={Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells.},
  author={Annett Linge and Karina Weinhold and Robert Bl{\"a}sche and Michael Kasper and Kathrin Barth},
  journal={The international journal of biochemistry & cell biology},
  year={2007},
  volume={39 10},
  pages={
          1964-74
        }
}
Bleomycin is an anti-cancer drug that induces both apoptosis and senescence, two processes thought to involve caveolin-1. Here we investigate the role of caveolin-1 in bleomycin-induced senescence. We show that bleomycin-treated A549 cells exhibit: senescence-like cell morphology; a senescence-associated increase in SA-beta-galactosidase activity; cell cycle arrest; and upregulation of p53 and p21. As predicted, we find that caveolin-1 amount increases in response to bleomycin-treatment and… CONTINUE READING
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