Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter

@article{Min2010DownregulationOC,
  title={Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter},
  author={J. Min and Seung-Oe Lim and G. Jung},
  journal={FEBS Letters},
  year={2010},
  volume={584}
}
Catalase, which decomposes reactive oxygen species (ROS), is reduced in hepatocellular carcinoma (HCC); however, the reasons are poorly defined. In this study, it is demonstrated that prolonged exposure to ROS induced methylation of CpG island II on the catalase promoter and downregulated catalase expression at the transcriptional level in HCC cell lines. In addition, hypermethylation of CpG island II was also observed in tumor tissues, together with a decrease in catalase mRNA and protein… Expand
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