Downregulation of cAMP response element-binding protein by lentiviral vector-mediated RNAi attenuates morphine withdrawal syndromes in rats.

Abstract

cAMP response element-binding protein(CREB) and the cAMP cascade play a pivotal role in the opiate-dependence. The blockade of this cascade is believed to attenuate signs of physical opiate withdrawal. A lentiviral vector (LV) expressing a small hairpin RNA (shRNA) to silence CREB in vitro and in vivo was used in this study. The effect of the shRNA on the… (More)
DOI: 10.1016/j.bbr.2012.04.026

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