Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells.

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, so-called statins, reduce the relative risk of a major coronary event by lowering the serum cholesterol level. In addition, statins may confer beneficial effects by cholesterol-lowering independent mechanisms, which are incompletely characterized. Because angiotensin II (Ang II) plays… (More)

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@article{Ichiki2001DownregulationOA, title={Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells.}, author={Toshihiro Ichiki and Ken Takeda and Tomotake Tokunou and Naoko Iino and Kensuke Egashira and Hiroaki Shimokawa and Koji Hirano and Hideo Kanaide and Akira Takeshita}, journal={Arteriosclerosis, thrombosis, and vascular biology}, year={2001}, volume={21 12}, pages={1896-901} }