Downregulation of active IKK beta by Ro52-mediated autophagy.

  title={Downregulation of active IKK beta by Ro52-mediated autophagy.},
  author={Motoko Niida and Makoto Tanaka and Tetsu Kamitani},
  journal={Molecular immunology},
  volume={47 14},
Upon activation, NF-kappaB translocates into the nucleus and initiates many biological events. This NF-kappaB signaling is mainly induced by the protein kinase IKK beta. Early in this signaling pathway, IKK beta is phosphorylated for activation by several factors, such as pro-inflammatory cytokines and the Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1). In cells expressing Tax protein, IKK beta is persistently phosphorylated, which chronically activates NF-kappaB signaling. But… CONTINUE READING
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