Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma

@article{Bae2017DownregulationOA,
  title={Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma},
  author={Jeong Mo Bae and Jung Ho Kim and Hyeon Jeong Oh and Hye Eun Park and Tae Hun Lee and Nam-Yun Cho and Gyeong Hoon Kang},
  journal={Modern Pathology},
  year={2017},
  volume={30},
  pages={267-277}
}
Acetyl-CoA synthetase-2 is an emerging key enzyme for cancer metabolism, which supplies acetyl-CoA for tumor cells by capturing acetate as a carbon source under stressed conditions. However, implications of acetyl-CoA synthetase-2 in colorectal carcinoma may differ from other malignancies, because normal colonocytes use short-chain fatty acids as an energy source, which are supplied by fermentation of the intestinal flora. Here we analyzed acetyl-CoA synthetase-2 mRNA expression by reverse… 
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