Downregulation of a protective Actinobacillus pleuropneumoniae antigen during the course of infection.

@article{Hennig1999DownregulationOA,
  title={Downregulation of a protective Actinobacillus pleuropneumoniae antigen during the course of infection.},
  author={Ingeborg Hennig and B Teutenberg-Riedel and Gerald Friedrich Gerlach},
  journal={Microbial pathogenesis},
  year={1999},
  volume={26 2},
  pages={53-63}
}
The persistence of Actinobacillus pleuropneumoniae in convalescent pigs significantly contributes to the distribution of disease. The downregulation of protective antigens in vivo as one possible mechanism responsible for this phenomenon was investigated using the small iron-regulated transferrin binding protein (TbpB-protein) as exemplary protective antigen. From a total of 21 pigs experimentally infected with A. pleuropneumoniae serotype 7 in three trials, bronchoalveolar lavage fluid (BALF… CONTINUE READING