Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice.

  title={Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice.},
  author={Motoyuki Tamaki and Yoshio Fujitani and Toyoyoshi Uchida and Takahisa Hirose and Ryuzo Kawamori and Hirotaka Watada},
  volume={1 2},
Zinc transporter 8 (ZnT8) has been identified as a β-cell-specific Zinc transporter expressed in insulin-secretory granules. Recent genome wide association studies indicated that Arg325Trp polymorphism of Slc30a8 encoding ZnT8 is associated with susceptibility to type 2 diabetes. As a first step towards understanding the pathogenic role of ZnT8 in diabetes, we evaluated the expression of ZnT8 in mouse pancreas. A rabbit polyclonal antibody specific to ZnT8 was raised. The raised ZnT8 antibody… CONTINUE READING
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